Friday, February 26, 2010

Breast and Gynecological Cancers in PJS Women

Scary stuff
Read at own risk

These are a few articles on the topic published between 2000 and 2010.
To read complete abstracts, go to
and enter PMID # into search box.

1. Int J Gynecol Cancer. 2009 Dec;19(9):1591-4.

A Case of Peutz-Jeghers Syndrome With Breast Cancer, Bilateral Sex Cord
Tumor With Annular Tubules, and Adenoma Malignum Caused by STK11 Gene Mutation.

Clements A, Robison K, Granai C, Steinhoff MM, Scalia-Wilbur J, Moore RG.

Providence, RI, USA

CASE:: A 43-year-old woman presented with an advanced-stage breast cancer
and a pelvic mass. The patient was treated with neoadjuvant chemotherapy
followed by laparotomy with a hysterectomy and
oophorectomy. Final pathologic examination revealed a concomitant breast
cancer with metastasis to the ovaries, bilateral stromal tumors with annular
tubules of the ovaries, and adenoma malignum of the cervix.
PMID: 19955943

2. Int J Gynecol Pathol. 2009 Nov 26.

An Unusual Case of Sex Cord Tumor With Annular Tubules With Malignant
Transformation in a Patient With Peutz-Jeghers Syndrome.

Barker D, Sharma R, McIndoe A, Blair E, Hall M, Gabra H, El-Bahrawy M.
London, UK.

We report a case of a 54-year-old Caucasian woman with an earlier diagnosis
of Peutz-Jeghers Syndrome (PJS) and sex cord tumor with annular tubules
(SCTAT). The sex cord stromal tumors showed aggressive malignant behavior with
repeated recurrence and metastasis.
PMID: 19952941

3. Arch Gynecol Obstet. 2008 Jul;278(1):75-7. Epub 2008 Jan 12.

Breast cancer, ovarian gonadoblastoma and cervical cancer in a patient with
Peutz-Jeghers Syndrome.

Kilic-Okman T, Yardim T, Gücer F, Altaner S, Yuce MA.

Edirne, Turkey

CASE: Multiple genital tract cancers in a 34-year-old woman with PJS are described. The patient, who was admitted to our department with severe vaginal bleeding, was performed right salpingo-oophorectomy because of pure gonadoblastoma in 1996. In 2003, concomitant to cervical carcinoma, breast cancer was diagnosed. Patient
underwent left modified radical mastectomy due to the invasive papillary
carcinoma. The patient received six cycles combination chemotherapy and radiation
therapy because of stage IIIB cervical cancer.

PMID: 18193442

4. J Korean Med Sci. 2006 Aug;21(4):752-7.

Peutz-Jeghers Syndrome with multiple genital tract tumors and breast
cancer: a case report with a review of literatures.

Song SH, Lee JK, Saw HS, Choi SY, Koo BH, Kim A, Yeom BW, Kim I.

Seoul, Korea.

We report here on the multiple genital tract neoplasms in a 41-yr-old
Korean woman with Peutz-Jeghers Syndrome (PJS). The patient presented with lower
abdominal pain. Her previous medical history was PJS and breast cancer.
Pelvic ultrasound showed a multilocular cyst at the right adnexal region,
diagnosed as bilateral ovarian mucinous borderline tumors. An ovarian sex cord tumor
with annular tubules was incidentally diagnosed together with a minimal
deviation adenocarcinoma of the uterine cervix and mucinous metaplasia of both the
Fallopian tubal mucosa and the endometrium.
PMCID: PMC2729904
PMID: 16891826

5. Eur J Surg Oncol. 2006 Feb;32(1):121-2. Epub 2005 Oct 24.

A case of bilateral breast cancer with Peutz-Jeghers syndrome.

Conneely JB, Kell MR, Boran S, Flanagan F, Kerin MJ.

Dublin, Ireland
PMID: 16246518

6. Pathologica. 2004 Jun;96(3):117-20.

Colonic adenocarcinoma and bilateral malignant ovarian sex cord tumor with
annular tubules in Peutz-Jeghers syndrome.

Ayadi-Kaddour A, Bouraoui S, Bellil K, Bellil S, Kchir N, Zitouna MM,
Haouet S.

Bab Saadoun, Tunisia

The authors report a case of Peutz-Jeghers syndrome in a young patient who developed a colonic adenocarcinoma in a hamartomatous polyp together with an incidentally discovered bilateral malignant sex cord tumours. We discuss its association with certain benign and malignant tumors and the risk of rare complications of these hamartomatous polyps.
PMID: 15524052

7. Gynecol Oncol. 2004 Jan;92(1):337-42.

An unusual admixture of neoplastic and metaplastic lesions of the female
genital tract in the Peutz-Jeghers Syndrome.

Mangili G, Taccagni G, Garavaglia E, Carnelli M, Montoli S.

Milan, Italy

CASE: Multiple genital tract neoplasms in a 41-year-old Italian woman with
PJS are described. The patient presented with abdominal pain due to
intussusception. A CT scan of the abdomen also showed a left adnexal mass, diagnosed
as ovarian mixed serous and mucinous borderline tumor. An ovarian
microscopic sex cord tumor with annular tubules (SCTAT) was incidentally diagnosed
together with a minimal deviation mucinous adenocarcinoma of the uterine
cervix. Also areas of typical hyperplasia of the tubal mucosa with mucinous
metaplasia were found.
PMID: 14751181

8. Gastroenterol Hepatol. 2001 Dec;24(10):495-9.

[Peutz-Jeghers syndrome associated with multiple epithelial tumors]

Cosme A, Ojeda E, San Vicente MT, Barrio J, Bujanda L, López P.

San Sebastián.

We present the case of a 68-year-old woman with Peutz-Jeghers
syndrome who presented with right kidney carcinoma and numerous small,
bilateral tumors of the sex cords with annular tubules of the ovary. Right
nephrectomy, double annexectomy and total hysterectomy were performed. The
patient died two years later following the development of rectal carcinoma
diagnosed by sigmoidoscopy and biopsy and an episode of obstructive jaundice
compatible with cholangiocarcinoma.

PMID: 11730618

9. Mod Pathol. 2000 Apr;13(4):466-70.

Malignant ovarian sex cord tumor with annular tubules in a patient with
Peutz-Jeghers syndrome: a case report.

Lele SM, Sawh RN, Zaharopoulos P, Adesokan A, Smith M, Linhart JM, Arrastia
CD, Krigman HR.

Galveston, Texas, USA.

We report a case of bilateral, malignant SCTAT developing in a 47-year-old
woman who had PJS, originally diagnosed as adenocarcinoma on cervicovaginal

PMID: 10786816

No comments:

Post a Comment