The PJS gene and multiple sclerosis
Please don’t worry about getting multiple sclerosis (MS) because you have PJS!
Please read on if you're interested in the research linking the PJS gene (STK11) to MS.
Dear PJS friends,
This 2015 medical journal article is about a
particular family in the Chicago region whose female members were affected by
both PJS and multiple sclerosis. (1) The authors tested the family to determine
their mutation on the PJS gene (STK11). Then, they tested over 1400 people with
multiple sclerosis to determine whether there’s a link between STK11 mutations
and multiple sclerosis.
They found, “Screening of DNA samples from
individuals with MS and healthy controls revealed that the STK11 genetic
variation was nearly twice as prevalent among women with relapsing remitting MS
compared to women without the disease. Although the genetic variant also
appeared to be more frequent in women with primary progressive MS than healthy
controls, the difference was not statistically significant. There was no
significant difference in the prevalence of the STK11 genetic variation between
both male and female MS patients and healthy controls overall.” (2)
Please don’t worry about getting multiple
sclerosis (MS) because you have PJS!
But if you or family members have or have had
a MS diagnosis and would like more information or to participate in their
research, I strongly encourage you to contact the article’s author, Douglas L.
Feinstein at dlfeins@uic.edu
Warmly,
Stephanie Sugars
References:
(1) A single-nucleotide polymorphism in
serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor
for multiple sclerosis.
Boullerne AI, Skias D, Hartman EM, Testai FD,
Kalinin S, Polak PE, Feinstein DL. ASN Neuro. 2015 Feb 18;7(1). pii:
1759091415568914. doi: 10.1177/1759091415568914. Print
2015 Jan-Feb. PubMed PMID: 25694554; PubMed
Central PMCID: PMC4342367.
free full text article:
(2) In plainer English
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